Case studies in reproducibility
نویسندگان
چکیده
منابع مشابه
Case Studies and Challenges in Reproducibility in the Computational Sciences
This paper investigates the reproducibility of computational science research and identifies key challenges facing the community today. It is the result of the First Summer School on Experimental Methodology in Computational Science Research. First, we consider how to reproduce experiments that involve human subjects, and in particular how to deal with different ethics requirements at different...
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Genome-wide association studies (GWAS) are widely used to discover genetic variants associated with diseases. To control false positives, all findings from GWAS need to be verified with additional evidences, even for associations discovered from a high power study. Replication study is a common verification method by using independent samples. An association is regarded as true positive with a ...
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چکیده در دنیای پیچیده ی امروز، تغییرات زیادی در زندگی بشری در حال وقوع اند و شاهد رقابت های بسیار فشرده ی جوامع در دستیابی به فناوری برتر و قدرت بیشترهستیم. به نظر می رسد که فرد وجامعه مجبورند به طریقی در وضعیت خویش دگرگونی ایجاد کنند تا از قافله ی علم، فناوری، و پیشرفت عقب نمانند. رشته مطالعات ترجمه نیز از این قاعده مستثنا نیست. علی رغم وسعت روز افزون پژوهش در این حوزه و میان رشته ای بودن مطال...
Reproducibility of quantitative (R)-[11C]verapamil studies
BACKGROUND P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease, and in drug resistant epilepsy. Positron emission tomography using the Pgp substrate tracer (R)-[11C]verapamil enables in vivo quantification of Pgp function at the human blood-brain barrier. Knowledge of test-retest variability is important for assessing changes over time or ...
متن کاملReproducibility of quantitative (R)-[C]verapamil studies
Background: P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer’s disease, and in drug resistant epilepsy. Positron emission tomography using the Pgp substrate tracer (R)-[C] verapamil enables in vivo quantification of Pgp function at the human blood-brain barrier. Knowledge of test-retest variability is important for assessing changes over time or ...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2011
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbq084